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Viagra: Worth The Risks? Viagra is among the most commonly used remedies for sexual impotence, even though there are several possible side effects. Most of these effects are rare and are only a problem if the recommended dose is exceeded. However, there is yet no data on the long-term, latent effects the drug has. Cortisol --- The Stress Hormone Experts claim that physical illness are among the negative effects of too much stress and anxiety. During stressful situations, the body stimulates the release of cortisol through the adrenal glands to cortisol. Cortisol is a natural steroid hormone that science experts refer to as the “stress hormone. It is known as the“stress hormone” because large amounts of this substance are released whenever a person feels stressed out.